This study explores the effectiveness of cluster-oriented strategies in promoting integration and diversification within Uzbekistan’s viticulture sector. The research adopts a mixed-methods approach, combining survey data, stakeholder interviews, and regression analysis across key grape-producing regions. Findings indicate that participation in viticulture clusters significantly improves productivity, income levels, and access to high-value markets through coordinated value chain integration and product diversification. Cluster participants also benefit from shared infrastructure, better access to innovation, and enhanced export potential. The results support the formulation of a national cluster development strategy aimed at strengthening institutional linkages, promoting agri-processing, and boosting rural livelihoods. This paper contributes to the growing body of literature on sustainable agriculture and provides practical policy guidance for transforming Uzbekistan’s viticulture industry into a competitive and resilient sector.