The study explored the relationship between human resource management operations and empowerment of teachers in public secondary schools of Panabo City Division. Also, it investigated the association of the involved variables and the domains of human resource management operations that significantly influenced empowerment of teachers. With the use of probability sampling, 150 secondary teachers in the public schools were selected as the respondents. Utilizing the descriptive-correlational survey method, the data collated were analyzed through the use of Mean, Product-Moment correlation and Regression Analysis. Results revealed that there was extensive human resource management operations and an extensive empowerment of teachers. Furthermore, there was a significant relationship between the two variables. Moreover, all domains of human resource management operations were found to have significantly influenced empowerment of teachers. Based on the findings, it was further suggested that higher officials in the Department of Education may identify means on how to help the school heads in strengthening the human resource management operations to ensure empowerment among teachers.