In this study teachers interactive instructional ability is a measure expected to improve the basic life skills of students. In this study, the researcher selected the 200 junior high school students in Labangal District, General Santos City as the respondents of the study. Stratified random sampling technique was utilized in the selection of the respondents. Non-experimental quantitative research design using descriptive-correlational method was employed. The data collected were subjected on the following statistical tools: Mean, Pearson Moment Product Correlation and multiple linear regression analysis. Findings revealed that teachers interactive instructional ability was rated as extensive, while, basic life skills of students in Labangal District, General Santos City was described as moderately extensive. Further, correlation analysis demonstrated that there is a significant relationship between teachers interactive instructional ability and basic life skills of students in Labangal District, General Santos City. Evidently, regression analysis proved that teachers interactive instructional ability in terms of teaching engagement, interaction, and feedback were significant predictors of basic life skills of students in Labangal District, General Santos City. The study, therefore, conducted for further utilization of findings through publication in reputable research journal.