This study sought to determine the social interaction approach in teaching science and academic proficiency of grade six pupils. Eventually, aimed to the magnitude of effect of the action initiated by the researcher on the academic proficiency of the research subjects was determined. This study made use of the quasi-experimental research design which is a non-equivalent control group pretest-posttest design. Non-equivalent design is a good design when the researcher has accessed to one group for experimentation (Vockel 2019). The researcher opted to use this design because the subjects of the study are intact group of learners. This study conducted in San Isidro Elementary School, Magsaysay South District Division of Davao Del Sur. The subjects of this study will be the 85 grade eight students – 43 are from section A which will be the controlled group and 42 are from section B which will be the experimental group. The composition of these two sections is homogeneous. Both learners from sections A and B had identical grades. This study made use of the non-random assignment of subjects where all learners of both sections A and B are involved as subjects of the study. This study revealed that the utilization of social interaction approach in teaching science and academic efficiency of grade 6 pupils has improved the academic performance of grade six pupils. It also revealed that there is magnitude of difference between the post test scores of the controlled and experimental groups.