Purpose: The aim of this research is to examine the specific challenges that female entrepreneurs experience in the e-commerce industry, as well as the achievements of the female-owned company Nykaa and to explore the strategies used by Nykaa's owner to conquer challenges in the e-commerce industry. E-commerce is the vehicle through which a nation's economy grows and women entrepreneurs contribute significantly to the economy. Women business owners are well-positioned to take full advantage of this digital opportunity. Approximately 20% of the 63 million micro, small, and medium-sized enterprises (MSMEs) in India are owned by women. Methodology: Descriptive analysis has taken for this study and for that secondary data has to be taken from journal articles, websites etc. Statistical techniques are taken like CAGR. Findings: Nykaa's net worth decreased in 2018 and 2019, but a positive trend starting in 2020 suggests a recovery and improvement in profitability. The organizational, financial, technological, and behavioral barriers that stand in the way of women entrepreneurs’ achievement in online business were identified by this study.