Employee well-being is a multidimensional construct that significantly influences organizational outcomes, including productivity, retention, and overall job satisfaction. This study aims to develop a comprehensive empirical framework to assess employee well-being by exploring three core dimensions: subjective, workplace, and psychological factors. Drawing on data from a diverse sample across various industries, this research examines how individual perceptions, organizational practices, and mental health factors contribute to well-being. Using a combination of surveys and quantitative analysis, the study assesses the impact of variables such as job security, work-life balance, and emotional resilience on employees’ perceived quality of life and engagement at work. Results reveal that fostering a supportive work environment, enhancing personal growth opportunities, and implementing mental health initiatives can substantially improve employee well-being. This framework provides insights for HR practitioners to design targeted interventions that address the distinct needs within each dimension, ultimately supporting both employees and organizational objectives.