This article examines the management of operational risks in global supply chains in the context of global instability. It examines the main problems related to political, economic, and climatic factors, as well as the specific characteristics of global supply chains, including their multi-tiered structure and geographical dependence. The analysis highlights adaptive strategies aimed at risk minimization, including proactive approaches such as supplier diversification, localization of production capacities, development of backup supply routes, and the adoption of digital technologies. The article also underscores the importance of integrating sustainable development principles and flexible approaches into supply chain management.