In this competitive and technological era where every organization is facing the problem of retention of best employee in their organization, perceived organizational support from employer plays a vital role in relation to retain the best pool of human resource to achieve the optimum height. Not only Perceived organizational support (POS) there has been significant contribution of employee well-being and work engagement in achieving the goal of any organization in respect of performance and productivity. This paper tries to put forward the conceptual framework that examines the role of perceived organizational support as a mediator in influencing employee well-being towards works engagement. The paper also tries to highlight the relationship between perceived organizational support with employee well-being and employee well-being with work engagement.