This study investigated entrepreneurship education and secondary school students’ skills acquisition in the Southern Senatorial Zone of Kano State, Nigeria. The objectives were to assess the availability of qualified teachers, the adequacy of infrastructural facilities, and the extent of their utilisation for entrepreneurship education. A descriptive survey design was adopted with a population of 3,438 SS III students. Using a multistage sampling approach, 100 students from 20 senior secondary schools were sampled. Data were collected using the ‘Students’ Skills Acquisition Questionnaire’ (SSAQ), which was validated by experts and found to be reliable, with a Cronbach’s Alpha of 0.77. Descriptive statistics were used to answer the research questions, while Chi-square tests were used to test hypotheses at the 0.05 significance level. Findings revealed that students’ acquisition of entrepreneurial skills was generally low. Results also indicated inadequate numbers of qualified teachers, poor provision of infrastructural facilities and underutilisation of available resources. Chi-square analysis confirmed significant relationships between teacher availability, infrastructure, utilisation, and students’ skills acquisition. The study concludes that entrepreneurship education in senior secondary schools in the Southern Senatorial Zone of Kano State, Nigeria, is ineffective and recommends government should increase teacher recruitment and training, improve infrastructure, and ensure efficient supervision for effective utilization of facilities.