This paper presents a comparative review of organizational policies and practices that promote work-life balance (WLB) among healthcare employees in different settings and cultural contexts. Given the demanding nature of medical work, including long shifts and high emotional stress, WLB has become a central concern in healthcare. The paper examines the design and effectiveness of WLB policies across various healthcare institutions—such as clinics, hospitals, and community health organizations—reviewing comparative studies in this area. Results demonstrate notable differences in organizational outcomes, employee perceptions, and policy approaches between countries and healthcare environments. The review also identifies common challenges and best practices for implementing WLB worldwide. Policymakers and healthcare institutions can create culturally sensitive and context-specific strategies to support employee well-being, reduce burnout, and improve patient care by considering these distinctions. Understanding these differences is crucial for developing tailored interventions that respect cultural norms and operational realities. The review highlights variations in policy effectiveness, challenges, and employee perceptions in different healthcare settings, offering insights on best practices.