This systematic literature review synthesizes 42 seminal works spanning 1755–2025 on entrepreneurial ecosystems, emphasizing university-based models (UBEE). Classical definitions portray the entrepreneur as a risk-bearer (Cantillon, 1755) evolving to an innovation-driven agent (Schumpeter, 1934; Drucker, 1985). Contemporary frameworks delineate 6–13 ecosystem domains (Isenberg, 2010; Stam, 2015). Universities function as orchestrators through Triple Helix synergies (Etzkowitz, 2008). A key gap persists in emerging economy contexts, with no studies on Eastern India. Thematic analysis identifies leadership and culture as the strongest predictors. Policy implications advocate balanced domain development rather than isolated factors. Future research should empirically validate UBEE in agri-dominant regions.