Today, education environment with declining birthrates, schools should not only emphasize how to improve the quality of education, arouse students’ interest in learning, stimulate their learning potential, and achieve educational goals; instead, they need to seek strategies to stabilize school management. This study takes college students as the research object, adds elements of the students’ perceptual innovation atmosphere, and explores the impact of school reform on school effectiveness; and discusses its reconciling effect between school reform and school effectiveness. The results of the study show that, school changes was positively and significantly affect school effectiveness; and the innovation atmosphere had moderating effects on school effectiveness, there are in school software changes and school hardware changes, respectively.