The study empirically investigated the relationship between entrepreneurial knowledge and organizational performance. The aim was to examine the influence of entrepreneurial knowledge on organizational performance. The study adopted the dynamic capability and relational view theory as the baseline theories for the study, the study also reviewed scholarly literature to ascertain the relationship between entrepreneurial knowledge on organizational performance. The results indicated a significant positive and strong relationship between entrepreneurial knowledge on organizational performance, we concluded that dimensions of entrepreneurial knowledge significantly relate to organizational performance. We, therefore, recommend that Owners and Managers should understand and develop a holistic approach to implementing overall management knowledge.