Universities contribute to economic development of a country. However, Universities experience scarcity of academic staff due to tremendous increase in student enrolment yet little attention is given to attraction and retention of staff for sustainable performance. This study determined the relationship between talent management practices (TMP), organization culture (OC) and sustainable organizational performance (SOP). Correlational and retrospective longitudinal designs were adopted and 51 Registrars purposively selected from 51 Chartered Universities responded to questionnaires. Secondary data was from accredited Government records. Reliability was confirmed by Cronbach Alpha coefficient 0.960 from pilot study on 5 Universities. Data was analyzed descriptively and inferentially. ...