This article examines the dynamics of absolute and relative mortality rates of the population of the Republic of Karakalpakstan over a 20-year period, and compares the position of these indicators in cities and villages. Also, in the context of regional cities of the Republic of Karakalpakstan, mortality rates were analyzed through cross-comparison, the indicators of regional cities were examined based on international criteria, and the causes of death of the deceased were analyzed. In addition, the dynamics of infant mortality in the Republic of Karakalpakstan was studied and an analysis was carried out of the causes of death by year, as well as those who died under the age of 1 year. A comparison and analysis of the dynamics of life expectancy at birth in the Republic of Karakalpakstan in recent years has been carried out, and conclusions and proposals have been made based on all the analyses.