The determinants of human development and regional inequality in Karnataka is analysed in this study. This study majorly examined the indicators of human development. This paper investigation is also based on secondary data using co-efficient variations (CV) examines overall inequality of human development within Karnataka. The study results are evident from 1991 to 2011 HDI values that the districts from the southern regions of the state have higher HDI values compared to northern regions of the state, signifying high intra-regional inequality in human development in the state. It observes that Kalaburgi the revenue region (Ballari, Bidar, Kalaburgi, Koppal, Raichur and Yadagiri districts) has stood lowest in the per capita income. Kalaburgi region‟s per capita income is less than half of the per capita income of the Bengaluru region.