This systematic review explores business disruptions and resilience strategies during the COVID-19 pandemic in India. Using the PRISMA framework, 31 academic and institutional studies were analyzed. Key findings highlight widespread failures due to liquidity constraints, supply chain disruptions, and digital unpreparedness. Simultaneously, new opportunities emerged via digitization, policy support, and business model adaptation. The study concludes with policy and business-level recommendations for fostering long-term resilience.