This study compares the health and wellbeing of rural and urban women in the Vijayapura District of Karnataka. It examines the many facets of well-being, including physical and mental health, eating patterns, access to and utilization of medical services, and program knowledge. Using questionnaires, anthropometric measures, and qualitative interviews, the study employs a mixed-methods approach to gather comprehensive data from women in both environments. Significant findings clearly distinguish between rural and urban locations. Urban women typically have better access to healthcare facilities, specialists, and health information, which is linked to higher rates of institutional deliveries and screens for non-communicable diseases. However, they are more likely to experience lifestyle-related issues like stress, obesity, and sedentary behavior. However, rural women face significant barriers to access, affordability, and availability of healthcare, which increases the risk of infectious diseases, maternal health problems, and nutritional deficiencies including anemia. Their health is additionally impacted by societal norms, occupational risks from agricultural work, and low health literacy, even though they often have larger informal community support networks. The study concludes that whereas urban women in Vijayapura District deal with health issues related to contemporary lifestyles, rural women primarily suffer socioeconomic limitations and institutional disparities in access to basic healthcare. To attain holistic wellbeing, tailored, situation-specific treatments are required. The ideas include developing urban wellness programs focused on mental health and lifestyle diseases, establishing targeted nutrition and sanitation initiatives, and bolstering primary healthcare and outreach programs in rural areas. Closing this equality gap would require integrated policy actions that address both the growing public health challenges in urban settings and the infrastructure shortcomings in rural communities.