This paper examines the relationship between Entrepreneurship and Empowerment. A case study is analyzed by the Researcher to understand the various factors responsible for women  empowerment through entrepreneurship. An NGO based at Mysore City acts as a Catalyst in socially transforming many of the women plights. Researcher conducted study using Descriptive cum   Diagnostic design to explain and analyze the hurdles of those HIV infected women folk.  This paper also wants to study the efficacy of the Social Work methods in understanding the problems of those women and how these methods extends helping hand through various professional Social Work skills.  This paper analyzes how a Social Work intervention counteracts the Psycho-social problems of their routine life and tries to conceive a practical model/ methodology to lead their individual as well as societal sustainable life.   

KEYWORDS: HIV/AIDS, Entrepreneurship, Women, Social Work