Every equity investor is advised to have enough information about the stock market before making any investment decisions. There are so many investment determinants which affect the investment in equity. This paper aims to study equity investment potential determinant of two pharmaceutical company for worth investments. In order to determine the equity investment potential of respective companies for the purpose of investment, we have selected five parameters such as Returns, Risk, Growth, Liquidity and Valuation respectively. For return performance we have chosen Gross profit margin, Operating profit margin relating to sales, Return on equity, Return on capital employed, Return on assets are selected to know the profitability of investments. For risk identification, we have used Volume of trade for market liquidity, current ratio for company liquidity, and Beta (β) for systematic risk and Debt equity ratio, Interest coverage ratio for financial risk. 3years sales growth, profit growth and sustainability of earnings growth are taken as proxy for growth potential assessment of companies. P/E ratio P/B ratio and EV/EBIT and price to sales along with margin of safety are used to know the valuation. Finally ranks are allotted respectively for all select variables to determine the worth of investment potential. In doing so, the least of total rank is taken as best, accordingly analysis was carried out and recommended for investment. The study Concludes that Glenmark Pharmaceutical company stands in merit. Hence, investment potential for more return on investment is high compared to NATCO Pharmaceutical company. Hence perspective investors can invest in Glenmark Pharmaceutical company if they invest in these two companies.