This study aims to analyze the mediating role of social support between anxiety and life satisfaction. This study provides guidance and suggestions for college students mental health and life satisfaction. This retrospective study reveals the importance of social support in alleviating students anxiety and improving students life satisfaction during the COVID-19 pandemic. We encourage governments to provide social support policies during quarantine measures, emphasizing the importance of social support during the epidemic. Secondly, colleges and universities should take active social support measures to buffer the anxiety symptoms caused by isolation measures and maintain a high level of life satisfaction.