The HyFlex model, a blend of in-person and online learning, has become increasingly popular in teaching academic research, particularly within Asian higher education institutions (HEIs). This study explored the best practices in implementing the HyFlex model for teaching academic research to college learners, focusing on its effectiveness and challenges in diverse educational settings. Using a qualitative research design, data were collected from interviews with faculty and students in several Asian HEIs employing the HyFlex model. The study identified key themes, including the benefits of flexible learning modes, the importance of culturally responsive teaching, the challenges of assessment and feedback, and the adaptation of technology for research teaching. Findings reveal that while the HyFlex model promotes increased student engagement and personalized learning, challenges persist in providing timely feedback and maintaining meaningful instructor-student interactions. Additionally, culturally tailored instructional approaches significantly contributed to the model's success. The implications of these findings suggest that educators should combine online and face-to-face interactions, adapt their feedback practices to hybrid learning environments, and consider cultural nuances in research teaching. Policy recommendations include formalizing the HyFlex model in academic settings and investing in faculty development programs. Future research should examine the long-term impact of the HyFlex model on students’ research skills and its scalability across different educational contexts