This study examined the relationship between the blue ocean strategy and the competitive advantage of breweries in South East Nigeria. Two objectives and hypotheses were formulated. A descriptive survey design was adopted for the study. The study population comprises 3467 staff of five (5) Breweries in South East Nigeria excluding clerical workers. The sample size of 358 was determined using the Taro Yamane formula. Pearson Product Moment Correlation Coefficient was used to test the research hypotheses. It was revealed from the findings that there exists a positive significant relationship between cost-focus strategy and the corporate image of breweries in South East Nigeria, and between making the competition irrelevant and cost leadership of breweries in South East Nigeria. The study concluded that a positive relationship exists between the blue ocean strategy and the competitive advantage of the breweries in South East Nigeria.