This is a quantitative study to investigate the effect of financial leverage on the managerial efficiency of large-scale enterprises in Cameroon. The study made use of the panel data spanning from 2013 to 2019 over a sample of 300 large-scale enterprises. The study’s objective was achieved empirically by using the two step generalised methods of moment system GMM estimation techniques and the pooled ordinary least square and the random effect estimation techniques for robust check. The result indicated that financial leverage is a significant positive determinant of managerial efficiency among large-scale enterprises in Cameroon. In light of the findings, the study recommends that enterprises should invest in managerial training programs to equip managers with the latest tools, knowledge, and strategies that can help improve managerial efficiency and, consequently, the financial performance of enterprises.