This study examines the role of Artificial Intelligence (AI) in optimizing Over-Dimensional Cargo (ODC) logistics operations in India. It analyzes how AI applications such as route optimization, real-time tracking, predictive maintenance, and resource allocation improve operational efficiency and cost effectiveness. The research also identifies key challenges in AI adoption, including infrastructure limitations, data management issues, and employee adaptability. Statistical analysis highlights the relationship between AI implementation and operational performance. The study concludes that effective integration of AI can enhance safety, compliance, and long-term competitiveness in the ODC logistics sector.