Indian micro, small and medium enterprise (MSME) sector plays a pivotal role in achieving the ambitious goal of self-reliantIndia. however, three key components that are essential for the success of MSMEs are, financial satiability, availability of skilled manpower and market competitiveness of their products to achieve import substitution as wellas export promotion. In order to achievethe goal of ‘Atmanirbhar Bharat’ or a self-reliant India, it is necessary to strengthen the domestic industries and their standing on a global stage. In this backdrop, the present study analyzes the role of MSMEsin achieving the self-reliant India.