The purpose of this research is to assess the factors that affect National Health Insurance Scheme (NHIS) enrollment in Ghana. Using convenience sampling method, 200 completed data were analyzed. The Statistical Package for Social Sciences (SPSS 25) was used in analyzing the relationships between the Independent variables and the dependent variable. Findings from the study indicated that there is a reasonable positive linear relationship between Enrollment Drive Features (Independent variables) and NHIS Enrollment (Dependent). Based on the findings, it is concluded that, a comprehensive package and awareness of a health insurance guarantee higher enrollment. The study recommends that the National Health Insurance Authority (NHIA) and its affiliate offices intensify the education and sensitization program about the scheme, its role and the feedback from the public.