Agricultural innovation plays a crucial role in enhancing productivity, sustainability, and economic growth in Uzbekistan's agrarian sector. However, the effective commercialization of these innovations faces several challenges, including regulatory barriers, limited access to finance, inadequate infrastructure, and knowledge gaps. This study aims to identify and propose strategies for improving the commercialization mechanisms for agricultural innovations in Uzbekistan. Utilizing a comprehensive research methodology that includes literature review, stakeholder analysis, case studies, and statistical analyses (correlation and regression), this research provides a detailed examination of the factors influencing innovation adoption and commercialization. The findings highlight that access to finance, quality of infrastructure, availability of training and extension services, strong market linkages, regulatory ease, and sustainability practices are critical determinants of successful commercialization. Correlation and regression analyses reveal strong positive relationships between these factors and the adoption rate of innovations. Furthermore, case studies from within Uzbekistan and similar contexts underscore the importance of government support, public-private partnerships, capacity building, and market development in driving innovation. Strategic recommendations based on PEST (Political, Economic, Social, and Technological) analysis suggest that streamlining regulatory processes, enhancing financial support, investing in infrastructure, strengthening educational programs, and promoting sustainable practices are essential for fostering an innovation-friendly environment. By addressing these key areas, Uzbekistan can significantly improve the commercialization of agricultural innovations, leading to increased food security, higher incomes for farmers, and sustainable agricultural development. This study contributes to the theoretical understanding of agricultural innovation diffusion and provides practical insights for policymakers, researchers, and practitioners aiming to enhance the commercialization ecosystem in Uzbekistan. Implementing the proposed strategies will help create a robust framework that supports agricultural innovation and drives economic growth in the region.