The article provides data on the composition of local entomopathogenic fungi that infect the box worm (cotton scoop), the identification of their pathogenicity and their toxic effect on the pest. As a result of the study, 20 strains of fungi belonging to 12 genera of hyphal fungi of the Deuteromycota ( Anamorfic fungi) division were identified. Analysis of the systematic composition of micromycetes showed the predominance of species of light-colored hyphomycetes , compared with dark-colored and tubercular. The largest number was noted in the genera Aspergillus Mich. - 5 species, Penicilium Lk., (3), Fusarium Lk. and Alternaria Nees ex Fr. (2), other genera included 1 species each. Pure cultures of Aspergillus flavus , A. fumigates, Trichotecium roseum , and Fusarium lateritium were used in the experiment to identify the toxicity of identified species to wax moth caterpillars. 10-day culture liquids had more than 2 times low activity compared to 30-day cultures, so Aspergillus flavus caused the death of 16.2%, A. fumigates - 15.2, Fusarium lateritium - 10.9, Trichotecium roseum - 8.0 % of larvae of early instars of the wax moth, while the data on the defeat of the wax moth with 30-day cultural liquids are 43.1; 42.4; 37.6; 36.4% respectively. The extracts had less toxicity than the filtrates, so Aspergillus flavus caused the death of 16.1%, A. fumigates - 14.2, F. lateritium - 15.0, Tr. roseum - 9.8% of larvae of early ages of the wax moth, and for larvae of older ages, the percentage of damage is somewhat lower.