stdClass Object
(
    [id] => 16403
    [paper_index] => 202506-01-022147
    [title] => PREFORMULATION AND EVALUATION OF EXTENDED RELEASE TABLET OF METOPROLOL SUCCINATE
    [description] => 
    [author] => Mr.Sandesh Nivas Gite, Ms. Ashwini Shelke, Dr. Sunil. S. Jaybhaye, Dr Swati Rawat
    [googlescholar] => 
    [doi] => 
    [year] => 2025
    [month] => June
    [volume] => 11
    [issue] => 6
    [file] => fm/jpanel/upload/2025/June/202506-01-022147.pdf
    [abstract] => The abstract of this study was to develop and evaluate an extended release (ER) tablet formulation of Metoprolol Succinate, a selective beta-1 adrenergic receptor blocker widely used in the treatment of hypertension, angina pectoris, and heart failure. Preformulation studies including solubility analysis, compatibility studies (using FTIR and DSC), and flow properties of drug and excipients were conducted to ensure the suitability of components for formulation. Extended release tablets were prepared by direct compression and wet granulation techniques using hydrophilic polymers such as hydroxypropyl methylcellulose (HPMC) as matrix-forming agents. The tablets were evaluated for physical parameters such as hardness, friability, thickness, drug content, and in vitro drug release profiles. The optimized formulation demonstrated consistent extended release over a 24-hour period, complying with USP dissolution specifications. Stability studies were also carried out as per ICH guidelines. The results suggest that the developed ER tablet of Metoprolol Succinate offers a promising approach for maintaining steady plasma drug concentration, improving patient compliance and therapeutic efficacy.
    [keywords] => •	Metoprolol Succinate
•	Extended Release Tablet
•	Preformulation Studies
•	Drug Release Kinetics
•	Sustained Release
•	Controlled Drug Delivery
•	Matrix Tablets

    [doj] => 2025-06-05
    [hit] => 
    [status] => 
    [award_status] => P
    [orderr] => 13
    [journal_id] => 1
    [googlesearch_link] => 
    [edit_on] => 
    [is_status] => 1
    [journalname] => EPRA International Journal of Multidisciplinary Research (IJMR)
    [short_code] => IJMR
    [eissn] =>  2455-3662 (Online)
    [pissn] => - --
    [home_page_wrapper] => images/products_image/11.IJMR.png
)
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