stdClass Object
(
    [id] => 18251
    [paper_index] => 202511-01-025087
    [title] => A REVIEW ON FOSFOMYCIN RESISTANCE: A REVIVAL DRUG FACING MODERN THREATS
    [description] => 
    [author] => Ms. Varsha D. Lendal, Ms. Pooja P. Ambhure, Dr. Sunil S. Jaybhaye, Ms. Vaishnavi R. Kulwant
    [googlescholar] => 
    [doi] => 
    [year] => 2025
    [month] => November
    [volume] => 11
    [issue] => 11
    [file] => fm/jpanel/upload/2025/November/202511-01-025087.pdf
    [abstract] => Fosfomycin, originally named phosphonomycin, was discovered in Spain in 1969. There are three forms of fosfomycin: fosfomycin tromethamine (a soluble salt) and fosfomycin calcium for oral use, and fosfomycin disodium for intravenous use. Fosfomycin is a bactericidal antibiotic that interferes with cell wall synthesis in both Gram-positive and Gram-negative bacteria by inhibiting the initial step involving phosphoenolpyruvate synthetase. It has a broad spectrum of activity against a wide range of Gram_positive and Gram-negative bacteria. It is highly active against Gram-positive pathogens such as Staphylococcus aureus and Enterococcus, and against Gram-negative bacteria such as Pseudomonasaeruginosa and Klebsiella pneumoniae.
Fosfomycin is a broad-spectrum bactericidal antibiotic that inhibits cell wall biosynthesis in both Gram-negative and Gram-positive bacteria. This antibiotic has a unique mechanism of action and inhibits the initial step in peptidoglycan biosynthesis by blocking the enzyme, MurA. Fosfomycin has been used successfully for the treatment of urinary tract infections for a long time, but the increased emergence of antibiotic resistance has made fosfomycin a suitable candidate for the treatment of infections caused by multidrug-resistant pathogens, especially in combination with other therapeutic partners.

    [keywords] => Fosfomycin Resistance; Molecular Mechanisms ,Fosfomycin; Pharmacokinetics; Multidrug Resistance; Antimicrobial Activity.
    [doj] => 2025-11-29
    [hit] => 
    [status] => 
    [award_status] => P
    [orderr] => 88
    [journal_id] => 1
    [googlesearch_link] => 
    [edit_on] => 
    [is_status] => 1
    [journalname] => EPRA International Journal of Multidisciplinary Research (IJMR)
    [short_code] => IJMR
    [eissn] =>  2455-3662 (Online)
    [pissn] => - --
    [home_page_wrapper] => images/products_image/11.IJMR.png
)
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