This study focused on assessing spatial activities around the Tamale Main Slaughterhouse in Ghana using ArcMap software. By employing geospatial analysis techniques, the research aims to provide insights into the distribution and intensity of various activities near the abattoir, including commercial, residential, and infrastructural elements. The study utilized ArcMap, a widely adopted Geographic Information System (GIS) software, to collect, process, and analyze spatial data. Primary data were gathered through field surveys, including interviews and observations, to obtain accurate information on land uses and activities. Satellite imagery and aerial photographs were also incorporated to enhance the spatial analysis. The research employed several spatial analysis techniques, such as proximity analysis, density mapping, and hotspot analysis, to assess the spatial patterns and relationships between the abattoir and its surrounding areas. The spatial analysis identified potential issues such as the encroachment of residential areas into the abattoir vicinity or the presence of critical infrastructure in close proximity to the slaughterhouse. The manure and the blood from the slaughterhouse have been good by-products for the production of poultry feed in a form of maggot. A big dugout should be made to channel the cow dung, blood and other waste products into it and covered to prevent the pollution of boreholes around the area.