Introduction Fluorosis is caused by excessive intake of fluoride. The dental effects of fluorosis develop much earlier than the skeletal effects in people exposed to large amount of fluoride. Acute high-level exposure to fluoride causes immediate effect of abdominal pain, excessive saliva, nausea and vomiting, seizure and muscle spasm may also occur. Although fluorosis is not a disease, its effects can be psychologically distressing and difficult to treat. Parental vigilance can play an important role in preventing fluorosis. Objective: To assess the knowledge regarding fluorosis among high school children in selected schools of Vadnagar. To assess the effectiveness of video assisted teaching program on knowledge regarding fluorosis among high school children in selected schools of Vadnagar. To find out the association of the knowledge with their selected demographic variable. Methodology: Research methodology is the systematic, theoretical analysis of the Method applied to a field of the study. Research methodology is one of the vital sections of a research, since the success of any research mostly depends upon the methodological issues that are followed in the execution of the research work. The role of methodology consists of procedures and techniques for concluding the study. This chapter deals with the methodological approach adopted for the study. It includes description of research approach, research design, setting of the study, population, sample, criteria for sample selection, sampling technique, development of the tool, scoring procedure, pilot study, data collection procedure and plan for data analysis. Conclusion: The finding of the study revealed that video assisted teaching is effective in increasing the knowledge regarding fluorosis.