Purpose of the study. Based on the assessment of the role of disturbances in various links of hemostasis in the pathogenesis of IMTV and ITP and establishing their connection with the stage of diseases, optimize the hemostasiological algorithm for diagnosing the pathologies under study. Material and methods: The study included 105 patients with IMTV (51 - in the stage of relapse, 54 - in the stage of remission); 135 patients with ITP (74 at the stage of relapse, 61 at the stage of remission) and 81 conditionally healthy persons without pathology of the hemostasis system (all examined were between the ages of 18 and 70). The study of the hemostasis system was carried out on a HumaClot Junior coagulometer (HC-4127, Germany) and an ALAT-2 “BIOLA” aggregation analyzer (AAS 748, Russia) using reagents “NPO RENAM, Russia”. Results and its discussion. Comprehensive study of the links of the hemostasis system: indicate the presence of pronounced coagulation disorders, which is one of the main mechanisms of the pathogenesis of IMTV and ITP. ITP is characterized by activation of the vascular-platelet link, moderate hypercoagulation, while ITP is characterized by a reduced activity of the vascular-platelet link of hemostasis.