The aim of the present study is to investigate the hypoglycemic, anxiolytic and anthelmintic activities of the methanolic extract of Microcos paniculata Leaves. The hypoglycemic activity was evaluated by measuring the blood glucose level of swiss albino mice, and anxiolytic activity was evaluated by hole board and elevated plus-maze tests on swiss albino mice. The anthelmintic activity was evaluated by measuring the paralysis and death times of adult earthworms. The methanolic extract of M. peniculata showed a highly significant (p< 0.001) hypoglycemic effect by reducing blood glucose levels with time, and the reduction is also dose-dependent. In the hole board test, the extract caused a large increase in the number of head dips. In the elevated plus-maze test, the extract caused a large increase in the amount of time spent in the open arm and a decrease in the amount of time spent in the closed arm. The extract showed highly significant (p< 0.001) anthelmintic activity by causing paralysis and death of earthworms in a short period, which is inversely proportional to increasing the concentration of extract. The evaluated results indicate the presence of hypoglycemic, anxiolytic and anthelmintic activities of this plant extract. Further investigation needs to be done to pick out the phyto-constituents responsible for these activities.