The article presents data on the study of the use of fungicides against rice blast in the Republic of Karakalpakstan. The fungicide Foliant BT, 22.5% с.e., showed the highest biological effectiveness against rice blast. (a.i. - Tebuconazole + triadimefon), which was 90.0-92.7%, and the yield was 68.7 t/ha. Then came the drug Amistar Top 32.5% s.c., taken as a standard, where the efficiency was 86.5-88.9%, with a yield of 64.2 t/ha, followed by the fungicide Merit 32.5% s.c. comparable with the standard. (a.i. - Azoxystrobin + Difenoconazole), where the biological efficiency was 85.8-87.1% with a yield of 66.5 t/ha.