Paracetamol is an active ingredient in the antipyretic and pain relievers class. Various brands of certain formulations are available on the market. The primary goal of the study was to compare 500 mg paracetamol tablet brands in vitro. In vitro evaluation guarantees quality, bioavailability and optimal therapeutic activity. The active metabolite of phenacetin, paracetamol, is widely used for headaches and pains and is one of the main ingredients in many cold and flu remedies. In the study, 500mg of paracetamol were selected from 5 different manufacturers standard tablets. The study was purely experimental and used in vitro testing (IP) and other official literature to evaluate the in vitro quality of paracetamol tablets using various analytical methods and procedures. In the post-evaluation phase, the following post-evaluation parameters were observed: Weight variation, Friability, Hardness, Content uniformity Within the prescribed limit