Background: Irrational usage and higher utilization of antimicrobial agents has become a major problem in all health care facilities all over the world, further give rise to antimicrobial resistance. Inappropriate use of antibacterial drugs may result in increased adverse drug reaction and also increase cost of treatment. The aim of the study was to evaluate and study drug utilization or drug distribution pattern of antimicrobial drugs. The objective of the study was to determine the average number of antibiotics prescribed per prescription, to evaluate the prescribing pattern and frequency, and to determine the most commonly prescribed antibiotic. Method: The present study was a prospective study done in general medicine ward of tertiary care teaching hospital to evaluate the utilization pattern of antibiotics. A total number of 208 patients were included in the study. Results: The ratio of male population is more as compared to females and most of the patients were in the age group of (61-70) years. The study report shows that most common class of antibiotics prescribed were cephalosporin (45.01%) followed by penicillin (14.74%), quinolones(13.94%), macrolides (7.56%), tetracyclines (4.38%). Study reports shows that (40.23%) of the prescription were prescribed with ceftriaxone (monocef). Conclusion: In this study maximum number of prescription had prescribed only one antibiotic as per W.H.O. A strict protocol for prescriber is now at utmost requirement to promote safe and rational use of antibiotic.