Background: World Health Organization (WHO) defines the quality of life as the perception of an individual of their position in life in the context of the value systems and culture in which they live and about their expectations, standards, goals, and concerns. This includes physical and mental health, employment, the environment, education, recreation and leisure time, social belonging, religious beliefs, safety, wealth, security, and freedom [1]. Various studies have shown the effect of parental education on quality of life [2, 3, and 4]. The importance of parental education and its effects on students quality of life is not implemented, which remains a gap. So, in this comparative study, we examined the impact of parental education on the quality of life of secondary and senior secondary students in rural and urban India. Aim, objective, methodology: The impact of parental education on quality of life of secondary and senior secondary students in rural and urban India. For this study, a well-structured Pre-tested was used and data is collected among secondary and senior secondary students of rural and urban Indian schools. Thereafter, the results were obtained by using Microsoft excel. Verbal and written consent was taken from participants involved in the study and another ethical clearance was taken from the ethical committee of the selected study area. Results: The obtained results show parents involvement is crucial for childrens growth of children. And development.