Thyroid hormones are very essential for normal metabolism, growth and development. It is extremely receptive and responds to stress and stimulation very quickly. According to recent studies, 13 out of every 100 people have thyroid issues. Among this, Hypothyroidism is one of the most prevalent thyroid disorder in India which is affecting one out of every ten persons. Although the diagnosis and treatment of hypothyroidism are considered as simple, there are large numbers of people with this condition who are not treated seriously. The main obstacle in Ayurveda is that there is no exact correlation of thyroid gland in Ayurvedic classics, where as the Galganda and Gandmala have been frequently used in the text. But Ayurvedic system of medicine is very futuristic and Caraka in 18th chapter of sutra sthana emphasized that there is no need to emphasize on the exact nomenclature of the disease. The thyroid condition can be compared as agni dushti. There will be a formation of ama because of that agni dushti. In a nut shell ama is a precursor state of a substance in transformation. Using these principles Srotoshodhana, Agnideepana, Pachana and Vatanulomana are the main principles in the treatment of Hypothyroidism. Here a case study of a patient who suffered from hypothyroidism and was successfully treated with multifactorial approach of Ayurveda like shodhana and shamana is selected. After the treatment, TSH was reduced from 18.48 to 4.63µg/mL.