DEVELOPMENT AND CHARACTERISATION OF POLYHERBAL PHYTOSOME GEL FOR DERMOCOSMETIC APPLICATIONS


Raslamol K, Hanan KS, Nithin Antony Basil, Priyanka Francis, Riswana Nargees
Department of Pharmaceutics, Nirmala College of Health Science, Meloor, Chalakkudi , Kerala
Abstract
Novel drug delivery system is a new approach to drug delivery the shows the limitations of the traditional drug delivery system. The effectiveness of any herbal medication is depend on the delivery of effective level of the therapeutically active compound. Therefore, phytosomes are recently introduced herbal formulations that are better absorbed and as a result they produce better bioavailability than the conventional phyto-molecules or botanical extracts. The aim and objective of the study is to develop polyherbal phytosome gel for dermocosmetic application using Couroupita Guianensis and Cassia Fistula extract. The phytosome are prepared by reflux method and were optimized. The formulations of phytosomes were analyzed for measurement of particle size & zeta potential, drug content, drug entrapment efficiency, percentage yield, in-vitro drug release studies and Exvivo permeation study.Then incorporate this phytosomal complex into gel formulation. Polyherbal phytosome gel formulation were evaluated by spreadability, drug content, measurement of pH, homogeneity, rheological studies
Keywords: novel drug delivery system, phytosomes, couroupita guianensis,cassia fistula, polyherbal phytosomal gel
Journal Name :
EPRA International Journal of Research & Development (IJRD)

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Published on : 2023-07-20

Vol : 8
Issue : 7
Month : July
Year : 2023
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