Vrana ropana or wound healing is a natural process occurring in the body. It gets delayed and transfigured to Dushtavrana, due to the vitiation of Doshas and microbial action, are analogous with Non-healing ulcer. Chronic non-healing ulcers affect as an economic burden to the healthcare system, by reducing the quality of life for those who are affected and often leading to serious events such as limb amputations or even premature deaths. Kampillaka is a drug mentioned for Krimihara and Vranaropana and studies have shown its anti-microbial effect against various micro organisms. In the current study the aqueous extract of Kampillaka (Mallottus philippensis) against pathogenic bacteria is evaluated in pus samples of subjects diagnosed with Dushtavrana by culture and sensitivity. With the current study it is evident that the mean zone of inhibition of aqueous extract of Kampillaka possess antimicrobial action against Staphylococcus spp., Pseudomonas spp. and E.coli. Further it is also obvious that as the concentration of aqueous extract of Kampillaka increases, the zone of inhibition also increases.