Inappropriate use of analgesics, because these drugs are over-the-counter drugs, can negatively impact the body. A plant that has potential as an antipyretic analgesic compound is mangosteen fruit. Many studies have explored the multiple benefits of natural ingredients, including mangosteen peel. The study aims to test the analgesic and antipyretic effectiveness of mangosteen skin methanol extract in Wistar rats. This study is an experimental research, with a post-test-only Only Control Group Design design that aims to explore mangosteen peels antipyretic and analgesic effects in March 2023. Analyzed with IBM SPSS 25 software, data normality test using Shapiro-Wilk. If the data is usually distributed, parametric statistical analysis is carried out in one-way ANOVA, while if the data is not normally distributed, data transformation is carried out. However, if the data is still abnormally distributed, an alternative test is carried out with non-parametric statistical analysis in the form of Kruskal-Wallis. The mangosteen peel methanol extract results contain various phytochemicals, namely Alkaloids, Saponins, Flavonoids, Tannins, and Steroids and Terpenoids. Conclusion Methanol extract from mangosteen skin has a significant antipyretic effect (P value = 0.014) after 5 hours of administration with an optimal dose of 600 mg/kg body weight. Mangosteen skin methanol extract has a significant analgesic effect (P value = 0.042) on nociceptive pain with an optimal dose of 600 mg/kg body weight.