End-stage renal disease (ESRD) patients undergoing hemodialysis often experience muscle cramps, a debilitating and distressing symptom that significantly affects their quality of life. Muscle cramps in this population can be attributed to various factors, including electrolyte imbalances, fluid shifts, and nerve dysfunction. While several interventions have been explored to manage muscle cramps in hemodialysis patients, this article focuses on the effectiveness of stretching leg exercises as a non-pharmacological approach. This comprehensive review discusses the current state of knowledge regarding the use of stretching leg exercises in managing muscle cramps among patients undergoing hemodialysis, highlights the potential benefits, and explores their integration into patient care. Additionally, we delve into the evidence supporting this approach, practical strategies for implementation, and future directions for research in this important area of renal care.