Cardiothoracic nursing is a specialized discipline within the field of nursing that focuses on the care of patients with heart and lung conditions. The importance of evidence-based practice (EBP) in nursing, particularly in the cardiothoracic domain, cannot be overstated. This research article aims to explore the significance of EBP in cardiothoracic nursing, shedding light on its critical role in improving patient outcomes and addressing the existing gap between research and clinical application. By conducting a systematic review of recent studies in the field, this article underscores the imperative of translating research findings into everyday nursing practice.