This paper delves into the study of fish infections caused by the cestode species Bothriocephalus opsariichthydis (Yamaguti, 1934) in the water bodies of the Surkhandarya region. The research discusses the cestodes impact on the fish, its life cycle, and pathogenic attributes. A significant finding of this study is the seasonal prevalence of infection, with a spike in the summer season. This heightened infection rate is intricately tied to temperature variations. The article also provides guidance on preventive strategies against botryocephalosis.