Modern research shows that herbal medicines are effective for health and do not cause side effects like chemical drugs. The development of herbal medicines that tend to have lower side effects and are safer is very important. One of the natural ingredients that has the potential to be used as an alternative is mangosteen peel. The purpose of this study was to analyse the effect of mangosteen (Garcinia mangostana l.) peel ethanol extract on wound healing after tooth extraction in rats. This laboratory experimental study used a complete randomised design with a post-test-only control group design pattern. The experimental animals used in this study were 32 male Wistar rats, physically healthy, 2-3 months old, with body weight between 200-250 grams. The rats will be divided into two groups, namely, 16 rats treated with 45% Ethanol of mangosteen fruit peel (Garcinia mangostana L) and 16 rats treated with 90% Ethanol of mangosteen fruit peel (Garcinia mangostana L) to see the comparison of accelerated wound healing after tooth extraction. The study used pure experiment with nonparametric Chi-Square Test, after testing showed that (p<0.05) means there is a significant difference between groups. Based on Chi-Square data analysis, there is a significant relationship between the number of fibroblast tissue per visual field in Wistar rats after tooth extraction by administering 45% Mangosteen Fruit Peel Ethanol Extract (Garcinia mangostana L) and 90% Mangosteen Fruit Peel Ethanol Extract (Garcinia mangostana L), p=0.007 (p<0.05). Based on the results and discussions that have been carried out in this study, it can be concluded that 45% and 90% ethanol extracts of mangosteen fruit peel (Garcinia mangostana L) are effective in accelerating wound healing time after tooth extraction of Wistar rats.