FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE GASTRO-RETENTIVE FLOATING TABLETS OF AMBROXOL HYDROCHLORIDE
Mr. Prakash Singh, Dr. Arun Patel, Mr. Shailendra Patel, Dr. Adiya Sahu, Mr. Vijay Pratap Ahirwar
Shri Ram Group of Institutions, Faculty of Pharmacy, Jabalpur, M.P.
Controlled release (CR) dosage forms have been extensively used to improve therapy with several important drugs. However, the development processes are faced with several physiological difficulties such as the inability to restrain and localize the system within the desired region of the gastrointestinal tract and the highly variable nature of the gastric emptying process. Ambroxol HCl is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Mucobrox, Lasolvan, Mucoangin, Surbronc and Lysopain. The substance is a mucoactive drug with several properties including secretolytic and secretomotoric actions that restore the physiological clearance mechanisms of the respiratory tract, which play an important role in the bodyâ€™s natural defence mechanisms.
Keywords: Controlled release (CR) dosage forms, Physiological difficulties, Gastric emptying process, Ambroxol HCl, Mucoactive drug.
Journal Name :
EPRA International Journal of Research & Development (IJRD)
Published on : 2023-11-08