Sahanasree Arella, Paddana Thanyasri, Paka Bhavana, M Sunitha Reddy
Jawaharlal Nehru Technological University Hyderabad, Center for Pharmaceutical Sciences Kukatpally-500085 Telangana
Abstract
Heterocyclic compounds, characterized by rings containing atoms beyond carbon, play a pivotal role in drug discovery due to their diverse structural configurations and significant biological activities. This review encompasses an extensive exploration of these compounds, focusing on their synthesis methods, structural diversity, biological activities, mechanisms of action, case studies, and prospects. The methods section outlines conventional chemical synthesis approaches alongside environmentally friendly and computationally guided methods. It highlights the importance of sustainable synthesis and computational design in the creation of diverse heterocyclic structures. Structural diversity is examined by showcasing common heterocyclic rings, while also delving into unique and atypical structures. Special emphasis is placed on the role of aromaticity in influencing bioactivity, shedding light on its significance in drug development. The review elaborates on the broad spectrum of biological activities exhibited by bioactive heterocycles, including their role in anticancer, antibacterial, antifungal, neuropharmacological, and antiviral applications. Mechanisms of action, such as target identification, cellular signaling pathways, pharmacokinetics, and pharmacodynamics, are elucidated to underline the intricate ways heterocyclic compounds interact within biological systems. Furthermore, the review presents case studies and recent discoveries that underscore the significance of heterocyclic compounds in drug development. Key studies and promising compounds in clinical trials are highlighted to showcase the potential and advancements in this field. Lastly, the challenges in drug development, emerging trends, and the potential for personalized medicine are discussed in the context of heterocyclic compounds. The review concludes by addressing future directions and the transformative role of emerging technologies in shaping the landscape of bioactive heterocycles for personalized therapeutic interventions.
Keywords: Heterocyclic Compounds, synthesis,biological application, various developments
Journal Name :
EPRA International Journal of Research & Development (IJRD)

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Published on : 2023-11-30

Vol : 8
Issue : 11
Month : November
Year : 2023
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