Phytoconstituents have been utilized as medicines for thousands of years, yet their application is limited owing to major hurdles like deficit lipid solubility, large molecular size and degradation in the gastric environment of gut. Recently, phospholipid-complex technique has unveiled in addressing these stumbling blocks either by enhancing the solubilizing capacity or its potentiating ability to pass through the biological membranes and it also protects the active herbal components from degradation. A majority of the plant constituents, specifically phenolic compounds, are hydrophilic and possesses major hurdles like poor lipid solubility, large molecular size, and degradation in the gut owing to their liable nature to acidic and enzymatic environment which limits their application in the therapeutic usage. To improve the bioavailability of these water soluble molecules in the body, phospholipids based drug delivery system has been found to be promising. Owing to their better biocompatibility and biodegradability, natural materials like polysaccharides, proteins and phospholipids have gained much attention. Phospholipid complex-technique, can serve as a potent drug delivery system for increasing therapeutic index which encapsulates, plant actives. In fact, these complexed actives are safer than its original form and can even serve as a better targeting agents to deliver these encapsulated agents at specific sites there by proving promising candidates in various medical fields for improving health aspects. This technique can be applied for herbal dosage forms and are often known as phytosomes. Present investigation deals with formulate phospholipid complex of hydroalcoholic extract of Smilax china for effective anti-diabetic effect.